Treatment of Oral Inflammatory Diseases with a New Mucoadhesive Prednisolone Tablet Versus Triamcinolone Acetonide Paste
نویسندگان
چکیده
Background: The existing clinical trials have shown that topical corticosteroids are often effective in the management of oral inflammatory diseases. The purpose of this study was to compare the effectiveness and safety of a new mucoadhesive prednisolone tablet with that of triamcinolone acetonid paste in the management of oral lesions such as RAS-EM -pemphigus vulgaris-recurrent intraoral herpes -OLP and chemical burn. Methods: In this randomized comparative study, 60 consecutive patients with oral lesions were recruited. The patients were divided into 2 groups, one receiving topical triamcinolone acetonid 0.1% paste and the other prednisolone 5 mg mucoadhesive tablet for 2 weeks. Results: The profiles of mean lesion sizes and mean pain measures did not show any difference between the prednisolone and triamcinolone groups. Conclusion: It was found that prednisolone 5mg table is useful as triamcinolone paste in the treatment of oral inflammatory lesions with minimal side effects.
منابع مشابه
Randomized trial of tacrolimus 0.1% ointment versus triamcinolone acetonide 0.1% paste in the treatment of oral pemphigus vulgaris
Background: Pemphigus vulgaris is a rare autoimmune disorder characterized by cutaneous and mucosal blistering. Surprisingly, the management of oral lesions has been detailed only infrequently. As current topical therapies for oral lesions are of limited efficacy, application of calcineurin inhibitors is considered to be a potential option. The aim of this essay was to investigate the efficacy ...
متن کاملThe Effect of Pimecrolimus Cream 1% Compared with Triamcinolone Acetonide Paste in Treatment of Atrophic-Erosive Oral Lichen Planus
Introduction: Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive types of OLP often have symptoms of soreness, and require proper treatment. The main treatment for OLP has been the administration of topical or systemic corticosteroids. The objective of this study was to compare the efficacy of adcortyl cream (triamcinolone acetonide in orabase...
متن کاملIntramuscular Administration of Steroids in Treatment of Rheumatoid Arthritis.
In a preliminary report (Zuckner, 1961) on intramuscular steroid therapy in patients with rheumatoid arthritis, results of approximately 100 injections of triamcinolone acetonide (hereafter referred to as TACTN)* and triamcinolone diacetate (or TDAC)t were described. The responses to this method of steroid administration were satisfactory in most cases, and compared favourably with those follow...
متن کاملTriamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis.
PURPOSE The aim of this study was to prepare the optimized oral paste formulation of Triamcinolone acetonide intended to be used in aphtous stomatitis. METHODS Plastibases were prepared using mineral oil and polyethylene (95:5). Oral paste formulations were prepared with different mixtures of three hydrocolloids solids, including gelatin, pectin and sodium carboxymethylcellulose, with differe...
متن کاملIntramuscular triamcinolone acetonide in chronic severe asthma.
Seventeen subjects with chronic severe asthma completed a 48 week prospective, double blind study with crossover of treatment at 24 weeks, in which triamcinolone acetonide 80 mg intramuscularly every four weeks was compared with oral prednisolone 10 mg daily. Spirometry, twice daily measurements of peak expiratory flow rate, and self assessment of asthma symptom scores showed significant improv...
متن کامل